The Effect of Glucagon and the Combined Effect of Glucagon and Secretin on Lower Esophageal Sphincter Pressure in Man

Abstract

Christiansen, J. & Borgeskov, S. The effect of glucagon and the combined effect of glucagon and secretin on lower esophageal sphincter pressure in man. Scand. J. Gastroent. 1974, 9, 615–618.

The effects of glucagon on resting and pentagastrin-induced lower esophageal sphincter (LES) pressure, and of secretin and glucagon + secretin on pentagastrin-induced LES pressure were studied in healthy volunteers. Glucagon 20 µg/kg injected intravenously decreased resting LES pressure 58%. Penta-gastrin-stimulated (0.5 µg/kg-hr) LES pressure was reduced 56% while secretin 1 U/kg decreased the pressure 41%, and the combined administration of glucagon and secretin 56%. No interaction between glucagon and secretin on pentagastrin-stimulated lower esophageal sphincter was found.

Key-words::

• Glucagon
• lower esophageal sphincter
• pentagastrin
• secretin