The Role of the Upper Duodenum in Controlling Gastric Acid Secretion in the Rat

Abstract

Lundberg, B. & Andersson, S. The role of the upper duodenum in controlling gastric acid secretion in the rat. Scand. J. Gastroent. 1974, 9, 623–627.

The effects of three types of duodenal ligation on gastric secretory volume, acidity, acid output, and ulcer frequency in rats have been compared with that of pylorus-ligation. The time between ligation and sacrifice varied between 3 and 16 hours. Sixteen hours after ligation, there was no change of gastric juice volume, whereas acidity and acid output were progressively reduced the further away from the pylorus the ligature was placed. The rats with duodenal ligatures had fewer ulcers and less severe ulcers compared with the pylorus-ligated ones. With shorter periods of ligation (3 or 5 hours), duodenal ligation reduced both volume and acid output by about the same order of magnitude, independently of where the duodenal ligature was placed. This finding is taken as evidence for a pH-sensitive, gastric inhibitory mechanism in the upper duodenum of the rat.

Key-words::

• Duodenum
• gastric secretion
• gastric ulcers
• pylorus-ligated rats