Acid Secretion and Serum Gastrin Following Insulin and 2-Deoxy-D-Glucose in Duodenal Ulcer Patients

Abstract

Emås, S., Svensson, S.-O. Dörner, Marianne & Kaess, H. Acid secretion and serum gastrin following insulin and 2-deoxy-D-glucose in duodenal ulcer patients. Scand. J. Gastroent. 1974, 9, 629–637.

Gastric acid secretion and serum gastrin level following insulin (0.2 U/kg i.v.) and 2-deoxy-D-glucose (2DG) (50 mg/kg i.v.) were compared in 30 unoperated male duodenal ulcer patients. The serum gastrin level was determined by radioimmunoassay. The basal gastrin level varied among patients and was unrelated to basal acid output and pH of basal secretion. 2DG produced a higher peak acid response and a higher peak gastrin level than insulin, suggesting that 2DG is a more powerful stimulant than insulin of both acid secretion and gastrin release. The acid response to insulin or 2DG was not related to the peak or increase of gastrin level, nor to the integrated gastrin response. Insulin failed to increase the gastrin level in 3 patients and 2DG in another patient, though both stimulants produced acid response in all patients. The absence of any relationship between acid secretion and gastrin level could suggest that the acid response to insulin and 2DG is produced mainly by a vagal action on the parietal cells while gastrin exerts a permissive role.

Key-words::

• 2-Deoxy-D-glucose
• duodenal ulcer
• gastric acid secretion
• gastrin immunoassay
• insulin