The Pancreatic Secretion of Enzymes in Rats Treated with Soybean Diet

Abstract

Fölsch, U. R. & Wormsley. K. G. The pancreatic secretion of enzymes in rats treated with soybean diet. Scand. J. Gastroent. 1974, 9, 679–683.

The secretory response to CCK-PZ and secretin has been studied in male Wistar rats which had been treated with a 20-day course of either raw (RSF) or heated (HSF) soybean flour. The overall biphasic pattern of enzyme secretion of the RSF rats was not different from the control (HSF) rats, and the maximal rate of secretion of trypsin was identical in the two groups of rats. However, outputs of amylase and trypsin were significantly increased in the RSF animals compared with control in response to the submaximal and supramaximal doses of CCK-PZ, because the secretion of enzymes was better sustained than control in the RSF rats. Despite the gross morphological changes in the pancreatic enzyme-secreting cells after treatment with RSF, the pattern of enzyme secretion is not qualitatively different from normal.

Key-words::

• Amylase
• cholecystokinin-pancreozymin
• pancreas
• secretin
• secretion
• soybean trypsin inhibitor
• trypsin