Gastric Secretory Inhibition Induced by Three Methyl Analogs of Prostaglandin E₂ Administered Intragastrically to Man

Abstract

Nylander, B. & Andersson, S. Gastric secretory inhibition induced by three methyl analogs of prostaglandin E₂ administered intragastrically to man. Scand. J. Gastroent. 1974, 9, 751–758.

In healthy male volunteers the inhibitory action on gastric secretion of three alkylated prostaglandin (PG) analogs has been studied, namely, 15(S)-15-methyl PGE2 methyl ester, 16.16-dimethyl PGE2 and 16, 16-dimethyl PGE2 methyl ester. Gastric secretion was stimulated by an intravenous infusion of pentagastrin in a dose of 0.6 μg/kg-hr. The PG analogs were administered intragastrically through the stomach tube 45 minutes prior to the start of the pentagastrin infusion. All three analogs produced gastric secretory inhibition in a dose-dependent fashion, the ED-,o being about 40 μg per subject. The percentage inhibition produced by the analogs was the same at different rates of gastric secretory output. We conclude that these three analogs of PGE2 are potent inhibitors of gastric secretion, and that they may eventually have a beneficial effect in the treatment of peptic ulcer.

Key-words::

• Gastric secretion
• methyl analogs of prostaglandin E₂
• inhibition