Gastric Secretory Inhibition by Certain Methyl Analogs of Prostaglandin E₂ following Intestinal Administration in Man

Abstract

Nylander, B., Robert, A. & Andersson, S. Gastric secretory inhibition by certain methyl analogs of prostaglanin E2 following intestinal administration in man. Scand. J. Gastroent. 1974, 9, 759–762.

In healthy male volunteers the effect on gastric acid secretion by methyl substituted analogs of prostaglandin E₂ (PGE₂) has been studied, namely 15(S)-15 methyl PGE₂ methyl ester, 16,16-dimethyl PGE2, and 16,16-dimethyl PGE₂ methyl ester. Gastric secretion was stimulated by an intravenous infusion of pentagastrin at a dose of 0.6 µg/kg-hr. The PGE₂ analogs were given into the intestine at levels of 90, 110, and 140 cm from the incisor teeth. 80 µg of 15(5)-15-methyl PGE₂ methyl ester given at 90 cm level caused significant inhibition of gastric secretion, but less than after intragastric administration, whereas the same dose given at 140 cm level had negligible effects. The other two compounds were almost ineffective even at a dose of 200 µg given at 90 cm level. It is concluded that all three compounds are considerably less effective following intestinal administration than when given intragastrically. This difference in activity between intragastric and intraintestinal administration is unexplained.

Key-words::

• Gastric secretion
• inhibition
• prostaglandin E₂ analogs