The Effect of Carbachol and Pentagastrin on the Gastric Secretion of Acid, Pepsin, and Intrinsic Factor(IF) in Man

Abstract

Vatn, M. H., Schrumpf, E. & Myren, J. The effect of carbachol and pentagastrin on the gastric secretion of acid, pepsin, and intrinsic factor (IF) in man. Scand. J. Gaslroenl. 1975, 10, 55-58.

Intravenous infusions of carbachol and pentagastrin were given separately or simultaneously in 6 healthy students. The volume of gastric secretion and the concentration and output of acid, pepsin, and IF increased significantly during infusion of carbachol alone, whereas the plasma gastrin concentration remained unchanged. Carbachol had no effect on the acid, pepsin, and IF secretion stimulated by pentagastrin. The results indicate an effect of carba-chol on acid, pepsin, and IF secretion, independent of changes in plasma gastrin concentration. No synergistic or potentiating effect was demonstrated between carbachol and pentagastrin.

Key-words::

• Carbachol
• gastrin
• hydrochloric acid
• hydrogen ion concentration
• intrinsic factor
• pepsin