Effect of Two Methylated Prostaglandin E₂ Analogs on Gastroduodenal Pressure in Man

Abstract

Nylander, B. & Andersson, S. Effect of two methylated prostaglandin E₂ analogs on gastroduodenal pressure in man. Scand. J. Gastroent. 1975, 10, 91-95.

The effect of two methylated analogs of prostaglandin E₂ (PGE₂), namely 16,16-dimethyl PGE₂ and 15(5)-15-methyl PGE₂ methyl ester, on gastroduodenal motility has been studied in healthy male volunteers. Oral administration of 140 μg of the 16-alkylated analog produced a significant decrease in motor activity in both the gastric antrum and the duodenum. 80 μg had no detectable effect on pressure. However, 80 μg of the 15-methylated analog administered directly into the duodenum caused an almost immediate inhibition of the duodenal motor activity. In view of previous findings on the inhibitory action of these two analogs on gastric acid secretion, it seems as if the gastrointestinal smooth muscles are less sensitive to the action of the analogs than are the oxyntic glands.

Key-words::

• Gastrointestinal motility
• inhibition
• prostaglandin E₂ analogs