Acetylsalicylic Acid and Gastrointestinal Bleeding Measurement of Blood Loss Using a Modified Radioactive Chromium Method

Abstract

Arvidsson, B., Magnusson, B., Sölvell, L. & Magnusson, A. Acetylsalicylic acid and gastrointestinal bleeding - measurement of blood loss using a modified radioactive chromium method. Scand. J. Gastroent. 1975, 10, 155-160.

A comparative study of the gastrointestinal blood loss during intake of a new buffered acetylsalicylic acid (ASA) preparation and plain ASA tablets has been performed. A modified radioactive chromium method was used. The ⁵¹Cr activity was considerably less than that used in previous methods, and no feces homogenization was necessary. The study was performed in 18 volunteers using a randomized crossover design. A significant reduction in gastrointestinal bleeding was registered during ingestion of the buffered ASA in comparison with the plain ASA tablets.

Key-words::

• Acetylsalicylic acid
• blood in feces
• chromium isotope labeling