Effects of Carbenoxolone Sodium and of Aspirin on Gastric Mucosal Potential Difference in Normal Subjects

P. N. BennettDepts. of Clinical Pharmacology and Gastroenterology, University College Hospital and Medical School, London, England

G. M. FrigoDepts. of Clinical Pharmacology and Gastroenterology, University College Hospital and Medical School, London, England

W. M. T. WeerasingheDepts. of Clinical Pharmacology and Gastroenterology, University College Hospital and Medical School, London, England

J. E. Lennard-JonesDepts. of Clinical Pharmacology and Gastroenterology, University College Hospital and Medical School, London, England

Abstract

Bennett, P. N., Frigo, G. M., Weerasinghe, W. M. T. & Lennard-Jones, J. E. Effects of carbenoxolone sodium and of aspirin on gastric mucosal potential difference in normal subjects. Scand. J. Gastroent. 1975, 10, 161-164.

The fall in potential difference (p.d.) across the gastric mucosa induced by aspirin has been studied before and after administration of carbenoxolone sodium in normal subjects. The subjects received 300 mg of carbenoxolone sodium daily for 14 days. The mean percentage fall in p.d. measured 10 cm distal to the cardia was unchanged.

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Effects of Carbenoxolone Sodium and of Aspirin on Gastric Mucosal Potential Difference in Normal Subjects

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Effects of Carbenoxolone Sodium and of Aspirin on Gastric Mucosal Potential Difference in Normal Subjects

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