Effects of 13-Nle-Motilin in Man - Inhibition of Gastric Evacuation and Stimulation of Pepsin Secretion

Abstract

Ruppin, H., Domschke, S., Domschke, W., Wünsch, E., Jaeger, E. & Demling, L. Effects of 13-nle-motilin in man - inhibition of gastric evacuation and stimulation of pepsin secretion. Scand. J. Gastroent. 1975, 10, 199-202.

In 3 healthy male volunteers, graded doses of 13-norleucine-motilin (13-nle-motilin) - synthetic analogue of motilin and biologically equivalent to the natural polypeptide - were given intravenously on separate days. Gastric emptying, as determined by means of a radioisotope method, was slowed down dose-dependently by increasing doses of 13-nle-motilin. This was in-dicated by increasing ‘half-lives’ and ‘starting indices’ of the gastric emptying process, and by decreasing pyloric loss rates, respectively. The gastric pepsin output rose markedly from the basal level during intravenous infusion of 13-nle-motilin.

Key-words::

• Gastric emptying
• man
• pepsin secretion
• synthetic motilin