Gastric Secretory Inhibition by Two 16-Methylated Analogs of Prostaglandin E₂ Given Intragastrically to Patients with Duodenal Ulcer Disease

Abstract

Nylander, B. & Andersson, S. Gastric secretory inhibition by two 16-methyl-ated analogs of prostaglandin E₂ given intragastrically to patients with duodenal ulcer disease. Scand. J. Gastroent. 1975, 10, 217-220.

The effects of two methylated analogs of prostaglandin E., (PGE.,), namely 16,16-dimethyl PGE;, and its methyl ester, on gastric acid and pepsin secretion have been studied in 5 ulcer patients. Both analogs produced significant inhibition of acid secretion in a dose-dependent fashion, but the effect was less pronounced than the inhibition found in a group of healthy volunteers, and it was necessary to give 140 μg of each analog to reach about the ED_fj0. The mean values of pepsin output and pepsin concentration were decreased following administration of PGE₂, but the individual results varied.

Key-words::

• Duodenal ulcer disease
• gastric secretion
• inhibition
• methyl analogs of prostaglandin E₂