The Effect of Cholecystokinin on Electrical Spike Potentials and Intraluminal Pressure Variations in the Human Small Intestine

Abstract

Öigaard, A., Dorph, S., Christensen, K. C. & Christiansen, L. The effect of cholecystokinin on electrical spike potentials and intraluminal pressure variations in the human small intenstine. Scand. J. Gastroent. 1975, 10, 257-262.

Electrical spike potentials and intraluminal pressure variations were recorded from the human duodenum and distal ileum before and after i.v. administration of 80 dog Ivy units of cholecystokinin. In the duodenum, quantitative calculations of motility gave identical values before and after drug administration, and results were identical in patients before and after chol-ecystectomy as well as in hernia patients without upper gastrointestinal disease. A decrease in amplitude of the spike potentials was observed in the duodenum during the first few minutes after drug administration in all groups. Recordings from the distal ileum in ileostomy patients showed a significant increase in motility after CCK administration, whereas the spike potential amplitude was unchanged.

Key-words::

• Cholecystokinin
• gastrointestinal motility
• ileostomy
• spike potentials