The Uptake of Vitamin B₁₂ by the Sediment of Jejunal Contents in Patients with the Blind-Loop Syndrome

Abstract

Schjönsby, H. & Hofstad, T. The uptake of vitamin B₁₂ by the sediment of jejunal contents in patients with the blind-loop syndrome. Scand. J. Gastroent. 1975, 10. 305-309.

Following preincubation of intrinsic factor- (IF-) bound ⁵⁷CoBi2 with the jejunal sediments of 6 patients with the blind-loop syndrome, the mean uptake by the sediments of IF-⁵⁷CoB₁₂ (28.1% ± 4.2% S.E.M.) was significantly higher than the mean uptake by jejunal sediments from 5 control patients (5.8% ± 3.5%) (p < 0.01). The uptake by the sediments significantly decreased when the incubations were carried out in the presence of lincomycin and neomycin. The jejunal sediments from the patients with the blind-loop syndrome inhibited the uptake of IF-⁵⁷CoB₁₂ by perfused rat intestinal segments (p < 0.01), whereas the sediments from the control patients had no such inhibitory effect (p > 0.5).

Key-words::

• Diverticulosis
• intestinal absorption
• intrinsic factor
• malabsorption syndromes
• vitamin B₁₂