4
Views
36
CrossRef citations to date
0
Altmetric
Articles

Humoral Immune System Activity in Inflammatory Bowel Disease

&
Pages 545-549 | Received 03 Mar 1975, Accepted 12 Apr 1975, Published online: 16 Oct 2020
 

Abstract

Teisberg, P. & Gjone, E. Humoral immune system activity in inflammatory bowel disease. Scand. J. Gastroent. 1975, 10, 545-549.

In vivo activation of complement components C3 and GBG as revealed by crossed immunoelectrophoresis reflects humoral immune system activity in disease. These methods have been applied to a material of 25 patients with ulcerative colitis (UC) and 29 patients with Crohn’s disease (CD). Signs of activity in the complement sequence were observed in approximately half the patients of both categories. Fifty blood samples from 30 healthy controls were all negative. The presence of complement activation was correlated with disease activity in both groups, and in patients with CD this could also be shown in longitudinal studies in single patients. In UC complement activation was correlated with the extent of the disease process. The serum levels of factors C4, GBG, and C3 in the patient groups did not differ significantly from those found in the normals.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.