Gastric Secretory Response to Graded Doses of Pentagastrin Alone or in Combination with Carbacholine in Unoperated Duodenal Ulcer Patients

Abstract

Roland, M. Gastric secretory response to graded doses of pentagastrin alone or in combination with carbacholine in unoperated duodenal ulcer patients. Scand. J. Gastroent. 1975, 10, 603-608.

Dose-response studies of pentagastrin-stimulated gastric secretion were per-formed in 6 unoperated duodenal ulcer patients. On different days penta-gastrin was given in doses of 0.15, 1.5, and 15 μg/kg/hr, either alone or in combination with carbacholine, 2 μg/kg/hr. There were no significant differences between mean acid or pepsin outputs or mean volumes of gastric juice after infusion of pentagastrin alone or pentagastrin plus carbacholine at any dose step of pentagastrin. The dose of pentagastrin required to elicit half maximal acid output (K_m) and the calculated maximal acid output (V_max) were the same for pentagastrin alone and pentagastrin plus carbacholine. Thus, carbacholine did not increase the sensitivity of the parietal cells to pentagastrin in the unoperated duodenal ulcer patients.

Key-words::

• Acid
• carbacholine
• duodenal ulcer
• gastric secretion
• pentagastrin
• pepsin
• stomach