Disaccharidase Activities in Intestinal Metaplasia - Contribution of Lysosomal and Brush Border Enzymes

Abstract

Gudmand-Höyer, E., Asp, N.-G. & Möllmann, K.-M. Disaccharidase activi-ties in intestinal metaplasia - contribution of lysosomal and brush border enzymes. Scand. J. Gastroent. 1975, 10, 653-656.

Maltase, sucrase, and lactase were measured at pH 4 and pH 6 in normal and intestinalized gastric mucosa. In the normal mucosa the low activities of maltase and lactase seemed to be entirely due to lysosomal enzymes with acid pH-optimum. In intestinal metaplasia, brush border maltase and sucrase, but not lactase, appeared. On the other hand, there was a significant increase in lysosomal lactase (ß-galactosidase) activity.

Key-words::

• Brush border
• disaccharidases
• glycosidases
• intestinal metaplasia
• lactase
• lysosomes
• maltase
• sucrase