Serum Gastrin Response to Food Stimulation in Male Azotemic Patients

Abstract

Gedde-Dahl, G. Serum gastrin response to food Stimulation in male azotemic patients. Scand. J. Gastroent. 1975, 10, 683-687.

In 37 patients with hypertension and/or renal disease, blood from a peri-pheral and a renal vein was drawn during renal vein catheterization. The serum gastrin concentrations were determined and found by paired com-parison to be statistically significantly (p<0.05) higher in the peripheral than in the renal vein. A test meal was given to 9 male controls and 7 male azo-temic patients, and the scrum gastrin concentration response determined. The mean fasting serum gastrin values were 173 ± 22 pg/ml in the group of patients versus 42 ± 5.5 pg/ml in the controls. The serum gastrin response was significantly higher and of longer duration in the azotemic patients than in the controls. The pentagastrin-stimulated gastric acid secretion was, how-ever, equal in the two groups.

Key-words::

• Azotemia
• food
• gastrin
• human
• hydrochloric acid
• hypertension
• radioimmunoassay
• stomach