The Effect of Beta-Adrenergic Blockade upon Basal and Pentagastrin-stimulated Gastric Acid Secretion and upon Gastrin Response to Food

Abstract

Kronborg, O. The effect of beta-adrenergic blockade upon basal and pentagastrin-stimulated gastric acid secretion and upon gastrin response to food. Scand. J. Gastroent. 1975, 10, 757-762.

Beta-adrenergic blockade with 10 mg of propanolol had no significant effect upon the spontaneous gastric acid secretion, while the maximum (pentagastrin) acid secretion was depressed in healthy subjects and patients with duodenal ulcer. The gastrin response to food was insignificantly higher during beta-adrenergic blockade. It is suggested that a minor part of the maximum acid secretion may be due to activation of beta-receptors, while the gastrin response to food is probably not related to activation of beta-receptors.

Key-words::

• Beta-adrenergic blockade
• duodenal ulcer
• food stimulation
• gastric acid
• gastrin
• pentagastrin
• propanolol