Gastric Mucosal Blood Flow and Pepsin Secretion in Dogs — Stimulation by 13-Nle-Motilin

Abstract

Koch, H., Domschke, S., Belohlavek, D., Domschke, W., Wünsch, E., Jaeger, E. & Demling, L. Gastric mucosal blood flow and pepsin secretion in dogs – stimulation by 13-nle-motilin. Scand. J. Gastroent. 1976, 11, 93-96.

In response to graded doses of intravenous 13-norleucine-motilin (13-nlemotilin) – a synthetic analogue of motilin and biologically equivalent to the natural polypeptide -, gastric mucosal blood flow (GMBF) in canine vagally denervated fundic pouches was studied using the aminopyrine clearance technique. As 13-nle-motilin did not exert any detectable effect on gastric secretion of hydrogen ions, intraluminal instillation of 160 mM HC1 was used to provide a pH gradient allowing aminopyrine to move into the pouch lumen. With increasing doses of 13-nle-motilin, GMBF increased to 148% of control values; pepsin secretion – due to augmented pepsin concentration – rose concomitantly. Enhanced pepsin secretion was not accompanied by an increase in cyclic 3’,5’-adenosine monophosphate seretion.

Key-words::

• Aminopyrine clearance
• cyclic AMP
• dog
• gastric mucosal blood flow
• H⁺ secretion
• Heidenhain pouch
• pepsin secretion
• synthetic motilin