The Enteroglucagon Response to Intrajejunal Infusion of Glucose, Triglycerides, and Sodium Chloride, and Its Relation to Jejunal Inhibition of Gastric Acid Secretion in Man

Abstract

Holst, J. J., Christiansen, J. & Kühl, C. The enteroglucagon response to intra-jejunal infusion of glucose, triglycerides, and sodium chloride, and its relation to jejunal inhibition of gastric acid secretion in man. Scand. J. Gastroent. 1976, 11, 297-304.

In a previous communication we demonstrated that pentagastrin-induced gastric acid secretion is strongly and equally inhibited by intrajejunal infusions of hypertonic glucose, hypertonic sodium chloride, and triglycerides. Samples of peripheral venous blood obtained during these experiments were now analysed for insulin, glucose, pancreatic glucagon, and enteroglucagon. Pancreatic glucagon was stimulated weakly only by triglycerides. Enteroglucagon secretion was strongly stimulated by glucose, moderately by triglycerides, and unaltered after sodium chloride. Insulin secretion was stimulated only during the glucose infusion. We concluded that enteroglucagon is not responsible for the jejunal inhibition of gastric acid secretion in man by jejunal administration of hyperosmolal NaCl solution but may participate in the inhibition evoked by jejunal administration of glucose or triglycerides. Furthermore, it is unlikely that enteroglucagon is in itself insulinogenic in man.

Key-words::

• Gastrointestinal hormones
• glucagon
• insulin