Gastric Acid Responses to Graded i.v. Infusion of Pentagastrin and Histalog in Peptic Ulcer Patients before and after Antrum-bulb Resection

Abstract

Bergegårdh, S., Broman, G., Knutson, U., Palmer, L., & Olbe, L. Gastric acid responses to graded i.v. infusion of pentagastrin and Histalog in peptic ulcer patients before and after antrum-bulb resection. Scand. J. Gastroent. 1976, 11, 337-346.

Gastric acid responses to graded i.v. infusion of pentagastrin and Histalog were determined in peptic ulcer patients. Single-day multiple-dose tests were performed. The sensitivity to the humoral stimuli as determined by the calculated ED₅₀’s was not significantly different for duodenal ulcer patients with moderate (DU_mod) or massive (DU_mass) observed hypersecretion or for gastric ulcer (GU) patients: median ED₅₀’s of pentagastrin were 6.2, 6.6, and 13.1 µg/h in 18 DU_mod, 22 DU_mass and 7 GU patients respectively, and median ED₅₀’s of Histalog were 16.6, 25.3, and 17.1 mg/h in 14 DU_mod, 10 DU_mass and 6 GU patients respectively. Antrum-bulb resection significantly reduced basal acid secretion and maximal acid responses to the humoral stimuli (about 45% reduction) but did not significantly change the loss of gastric contents to the intestine or the sensitivity to the humoral stimuli (median EDso of pentagastrin increased from 5.2 to 6.7 µg/h in 14 patients, and median ED₅₀ of Histalog increased from 16.0 to 20.8 mg/h in 12 patients), suggesting that the intact antrum-bulb region of the ulcer patient is controlling the capacity to secrete acid, and indicating that antrum-bulb gastrin is an important trophic factor for the parietal cells in man.

Key-words::

• Gastrectomy
• gastric acidity determination
• pentagastrin
• peptic ulcer
• pyloric antrum