2
Views
11
CrossRef citations to date
0
Altmetric
Articles

Regional Ileitis (Crohn’s Disease)

II. Electrolyte and Water Movement in the Ileum during Perfusion with Bile Acids

&
Pages 487-490 | Received 09 Dec 1975, Accepted 20 Jan 1976, Published online: 16 Oct 2020
 

Abstract

Krag, B. & Krag, E. Regional ileitis (Crohn’s disease). II. Electrolyte and water movement in the ileum during perfusion with bile acids. Scand. J. Gastroent. 1976, 11. 487-490.

Electrolyte and water movement was studied by steady state perfusion technique in the ileum of 11 patients with regional ileitis (Crohn’s disease). Six patients who at the time of investigation had diarrhoea showed a constant secretion of salts and fluid during perfusion with control perfusate. Per 24 hours, the ileal effluents to colon would exceed the normal amount by 1-2 litres. In the 5 patients without diarrhoea the absorption patterns were normal. Electrolytes and water moved in parallel. Dihydroxy bile acids enhanced secretion or decreased absorption respectively, in the two groups of patients. It is concluded that functional disturbances of salt and water absorption in the inflamed ileum may be of significant physiological importance in the pathogenesis of diarrhoea observed in patients with regional ileitis.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.