Somatostatin Inhibits Insulin-Stimulated Gastrin Release and Gastric Secretion of Acid, Pepsin, and Intrinsic Factor (IF) in Duodenal Ulcer Patients

E. SchrumpfResearch Laboratory of Gastroenterology, Dept. IX, Ullevål Hospital, Med. Dept. B, Aker Hospital, and Surgical Dept., Diakonhjemmets Hospital, Oslo, Norway

M. H. VatnResearch Laboratory of Gastroenterology, Dept. IX, Ullevål Hospital, Med. Dept. B, Aker Hospital, and Surgical Dept., Diakonhjemmets Hospital, Oslo, Norway

K. F. HanssenResearch Laboratory of Gastroenterology, Dept. IX, Ullevål Hospital, Med. Dept. B, Aker Hospital, and Surgical Dept., Diakonhjemmets Hospital, Oslo, Norway

L. S. SembResearch Laboratory of Gastroenterology, Dept. IX, Ullevål Hospital, Med. Dept. B, Aker Hospital, and Surgical Dept., Diakonhjemmets Hospital, Oslo, Norway

J. MyrenResearch Laboratory of Gastroenterology, Dept. IX, Ullevål Hospital, Med. Dept. B, Aker Hospital, and Surgical Dept., Diakonhjemmets Hospital, Oslo, Norway

Abstract

Schrumpf, E., Vatn, M. H., Hanssen, K. F., Semb, L. S. & Myren, J. Somatostatin inhibits insulin-stimulated gastrin release and gastric secretion of acid, pepsin, and intrinsic factor (IF) in duodenal ulcer patients. Scand. J. Gastroent. 1976, 11, 517-520

The effect of somatostatin (0.6 mg/hour) on insulin-stimulated gastrin release and gastric secretion of acid, pepsin, and IF has been examined in 6 unoperated patients with duodenal ulcer. Gastrin release and gastric secretion of acid, pepsin, and IF in response to insulin alone (0.15 IU/kg bw. iv.) were significantly reduced by simultaneous administration of somatostatin. This finding indicates an inhibitory effect of somatostatin on insulin-induced gastrin release and gastrin secretion in addition to the already known effects of somatostatin.

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Somatostatin Inhibits Insulin-Stimulated Gastrin Release and Gastric Secretion of Acid, Pepsin, and Intrinsic Factor (IF) in Duodenal Ulcer Patients

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Somatostatin Inhibits Insulin-Stimulated Gastrin Release and Gastric Secretion of Acid, Pepsin, and Intrinsic Factor (IF) in Duodenal Ulcer Patients

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