Effect of Intrajejunal Fat on Meal-stimulated Acid and Gastrin Secretion in Man

Abstract

Christiansen, J., Rehfeld, J. F. & Stadil, F. Effect of intrajejunal fat on meal-stimulated acid and gastrin secretion in man. Scand. J. Gastroent. 1976, 11, 673-676

The effect of intrajejunal fat infusion on meal-stimulated gastric acid and gastrin secretion was studied in 8 healthy volunteers. Intrajejunal fat significantly reduced the acid response to a meal, measured by intragastric titration, as compared to intrajejunal infusion of saline. While serum gastrin concentrations rose from fasting levels to a constant plateau after the meal when saline was infused, fat infusion resulted in a transitory decrease in serum gastrin concentration followed by a significant increase. It is concluded that inhibition of gastrin release only plays a minor role, if any, in the observed fat-induced jejuanl inhibition of meal-stimulated acid secretion.

Key-words::

• Acid inhibition
• gastrin
• intestinal phase