Inhibitory Effect of Pancreatic Juice on the intestinal Uptake of Vitamin B₁₂

Abstract

Von der Lippe, G. Inhibitory effect of pancreatic juice on the intestinal uptake of vitamin B₁₂. Scand. J. Gastroent. 1976, 11, 697-703

Rat pancreatic juice (RPJ) reduced the mean uptake of ⁵⁷CoBu bound to rat intrinsic factor (IF) by perfused rat intestinal segments from 30.1 ±2.4 (pg ⁵⁷CoB₁₂ per cm intestine ± S.E.M.) to 26.7 ± 2.4 (p<0.05). RPJ activated with cnterokinase reduced the uptake from 22.8 ± 2.8 to 16.1 ± 1.9 (p<0.05). RPJ also reduced the uptake from 15.8 ± 2.3 to 8.3 ± 2.0 (p<0.01) in segments from partially pancreatectomized rats. Rat bile abolished the inhibitory effect of RPJ. The results indicate that in the absence of bile the exocrine pancreatic secretion is capable of inhibiting the intestinal uptake of vitamin B₁₂.

Key-words::

• Bile
• intestinal absorption
• intestinal secretions
• intrinsic factor
• pancreatic disease
• pancreatic juice
• vitamin B₁₂
• vitamin B₁₂ deficiency