Pressure-Responses to Cholecystokinin in the Fundus and Antrum of Isolated Guinea-pig Stomachs

Abstract

Gerner, T., Mæhlumshagen, P. & Haffner, J. F. W. Pressure-responses to cholecystokinin in the fundus and antrum of isolated guinea-pig stomachs. Scand. J. Gastroent. 1976, 11, 823-827

Cholecystokinin produced dose-dependent increases in motor activity in antral and fundal pouches of isolated guinea-pig stomachs. The response was immediate; the motor activity increased to a peak within 2 min, then decreased somewhat, but stabilized within 5 min at a value that was higher than before addition of cholecystokinin. In the antral pouches the response consisted of an increase in the amplitude of the rhythmic contractions; in the fundal pouch it was seen as an increase in basal pressure. The antral response was significantly greater in pouches distended to an initial basal pressure of 15-25 cm H2O than in undistended pouches. The fundal response was not enhanced by distension.

Key-words::

• Antrum
• cholecystokinin
• fundus
• gastric motility
• pancreozymin