Effect of Pentagastrin on Blood Flow Distribution in the Stomach of Cats with Gastric Ulcer

Abstract

Ulcer was induced in the anterior wall of the antrum by injection of acetic acid solution. Carbonized microspheres 15 ± 5 μ in diameter and labelled with ⁸⁵Sr and ¹⁴¹Ce were used to measure blood flow in different regions and layers of the stomach. The radioactivity of the blood and tissue samples was determined, and the blood flow was calculated for each tissue sample. Three groups of anaesthetized animals were used: 1) animals with normal stomachs, 2) animals with normal stomachs given pentagastrin, 3) animals with a one-week ulcer given pentagastrin. In animals with normal stomachs given pentagastrin during 20 minutes, the mucosal blood flow increased in all areas of the stomach apart from the antrum. In animals with a gastric ulcer pentagastrin was not found to influence the mucosal blood flow significantly. Pentagastrin was not found to change the muscularis flow in animals with normal stomachs, or in animals with a gastric ulcer.

Key-words:

• Blood circulation
• gastric ulcer
• microspheres
• pentagastrin
• stomach