Lysozyme in Plasma and Neutrophilic Granulocytes in Ulcerative Colitis and Crohn's Disease

Abstract

The concentration of lysozyme in plasma (P) and in neutrophil leucocytes (N) was determined by a turbidimetric method in 32 patients with ulcerative colitis (U.C.), 11 patients with Crohn's disease (C.D.), 9 patients with haemor- rhagic proctitis, and 39 healthy volunteers. In active U.C., P was significantly elevated (p<0.05), whereas C.D. showed normal values. Corresponding N was significantly reduced in active U.C. (p<0.05) but normal in C.D. In calculating the ratio N/P, highly significant lower values were found in active U.C. (p<0.001) compared to normal levels in C.D. The high P in active U.C. is presumed to reflect an accelerated destruction of neutrophil leucocytes as well as an intensified turnover rate. The reduced N is probably attributable to an inhibited synthesis. The findings suggest that lysozyme determinations are valuable in the differential diagnosis of active U.C. and C.D.

Key-words:

• Colitis
• ulcerative
• Crohn's disease
• lysozyme
• neutrophil leucocytes
• plasma