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Scandinavian Journal of Gastroenterology Volume 19, 1984 - Issue 1
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Original Articles

Are All Gliadins Toxic in Coeliac Disease?

An in Vitro Study of α, β, γ, and w Gliadins

P. D. HowdleDept. of Medicine, St. James's University Hospital, Leeds, and Gastroenterology Unit, Dept. of Medicine, Guy's Hospital and Medical School, London, United Kingdom
,
P. J. CiclitiraDept. of Medicine, St. James's University Hospital, Leeds, and Gastroenterology Unit, Dept. of Medicine, Guy's Hospital and Medical School, London, United Kingdom
,
F. G. SimpsonDept. of Medicine, St. James's University Hospital, Leeds, and Gastroenterology Unit, Dept. of Medicine, Guy's Hospital and Medical School, London, United Kingdom
&
M. S. LosowskyDept. of Medicine, St. James's University Hospital, Leeds, and Gastroenterology Unit, Dept. of Medicine, Guy's Hospital and Medical School, London, United Kingdom
Pages 41-47 | Received 15 Nov 1982, Accepted 18 Mar 1983, Published online: 30 Apr 2018
 
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Abstract

The toxicity of α, β, γ, and w gliadins for small-intestinal mucosa has been assessed by means of an organ culture technique. The results suggest that all these gliadin fractions are toxic to coeliac mucosa in vitro.

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