Additional Antacid Does Not Increase the Effect of Cimetidine in Gastric Ulcer Disease

S. J. RuneMedical Dept. F, Glostrup University Hospital, Glostrup; Surgical Dept., Ribe County Hospital, Ribe; and Medical Dept.C. Herlev University Hospital, Herlev; Denmark

K. G. JensenMedical Dept. F, Glostrup University Hospital, Glostrup; Surgical Dept., Ribe County Hospital, Ribe; and Medical Dept.C. Herlev University Hospital, Herlev; Denmark

H. R. WulffMedical Dept. F, Glostrup University Hospital, Glostrup; Surgical Dept., Ribe County Hospital, Ribe; and Medical Dept.C. Herlev University Hospital, Herlev; Denmark

F. BendtsenMedical Dept. F, Glostrup University Hospital, Glostrup; Surgical Dept., Ribe County Hospital, Ribe; and Medical Dept.C. Herlev University Hospital, Herlev; Denmark

J. LindskovMedical Dept. F, Glostrup University Hospital, Glostrup; Surgical Dept., Ribe County Hospital, Ribe; and Medical Dept.C. Herlev University Hospital, Herlev; Denmark

J. MejerMedical Dept. F, Glostrup University Hospital, Glostrup; Surgical Dept., Ribe County Hospital, Ribe; and Medical Dept.C. Herlev University Hospital, Herlev; Denmark

M. HøjlundMedical Dept. F, Glostrup University Hospital, Glostrup; Surgical Dept., Ribe County Hospital, Ribe; and Medical Dept.C. Herlev University Hospital, Herlev; Denmark

V. R. NissenMedical Dept. F, Glostrup University Hospital, Glostrup; Surgical Dept., Ribe County Hospital, Ribe; and Medical Dept.C. Herlev University Hospital, Herlev; Denmark

L. WillumsenMedical Dept. F, Glostrup University Hospital, Glostrup; Surgical Dept., Ribe County Hospital, Ribe; and Medical Dept.C. Herlev University Hospital, Herlev; Denmark

E. AgnerMedical Dept. F, Glostrup University Hospital, Glostrup; Surgical Dept., Ribe County Hospital, Ribe; and Medical Dept.C. Herlev University Hospital, Herlev; Denmark

L. TougaardMedical Dept. F, Glostrup University Hospital, Glostrup; Surgical Dept., Ribe County Hospital, Ribe; and Medical Dept.C. Herlev University Hospital, Herlev; Denmark

E. KristensenMedical Dept. F, Glostrup University Hospital, Glostrup; Surgical Dept., Ribe County Hospital, Ribe; and Medical Dept.C. Herlev University Hospital, Herlev; Denmark

K.-M. MøllmannMedical Dept. F, Glostrup University Hospital, Glostrup; Surgical Dept., Ribe County Hospital, Ribe; and Medical Dept.C. Herlev University Hospital, Herlev; Denmark

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Abstract

Eighty-one adult outpatients with endoscopically confirmed gastric ulceration were treated with cimetidine (1 g/day). In addition, the patients were allocated at random to either intensive antacid treatment or placebo treatment. This part of the study was double-blind. It was found that additional antacid treatment had no effect on ulcer healing and symptoms in cimetidine-treated gastric ulcer patients. The results were similar in patients with corpus ulcers and patients with prepyloric ulcers.

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Additional Antacid Does Not Increase the Effect of Cimetidine in Gastric Ulcer Disease

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Additional Antacid Does Not Increase the Effect of Cimetidine in Gastric Ulcer Disease

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