2
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Plasma Alpha-Lipoprotein Pattern and LCAT Activity in Acute Viral Hepatitis in Children

, , , , &
Pages 76-80 | Received 27 Dec 1982, Accepted 18 Mar 1983, Published online: 30 Apr 2018
 

Abstract

The alpha-lipoprotein (a-Lp) electrophoretic pattern on agarose gel was studied serially in 65 children with acute viral hepatitis. In seven cases the high-density lipoprotein fractions (HDL) were also separated by ultracentrifugation and studied in relation to lecithin:cholesterol acyltransferase activity (LCAT) during the acute phase and recovery. The a-Lp band was initially absent on electrophoresis in 36 cases and never appeared in 3 of the children who died. In those who survived a-Lp reappeared with clinical improvement even before a definite increase in S-ASAT and bilirubin was evident. In the seven children in whom it was measured LCAT activity ranged during the acute phase from 17.4 to 57 nmol h-1 ml-1. In patients with initially ‘normal’ LCAT activity (group I. no. = 3) HDL was normal both in amount and composition. In patients with ‘low’ LCAT (group II. no. = 4) HDL was reduced and of abnormal composition. In both groups the a-Lp band was absent or considerably reduced on electrophoresis. In the latter group LCAT activity increased significantly on recovery, as did the amount of HDL which became normal in composition. These results suggest that in acute viral hepatitis in children changes in composition and concentration of HDL depend on the degree of hepatic functional disturbance, as judged by plasma LCAT activity. Nevertheless, it appears that HDL electrophoretic behaviour may be abnormal during the early stage of the disease while plasma LCAT activity is not significantly affected.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.