Bacterial Colonization and Nitrite Concentration in the Achlorhydric Stomachs of Patients with Primary Hypogammaglobulinaemia or Classical Pernicious Anaemia

J. M. DolbyThe Clinical Research Centre and Northwick Park Hospital, Harrow, Middlesex, and the Bacterial Metabolism Research Laboratory, Central Public Health Laboratory, London, U.K.

A. D. B. WebsterThe Clinical Research Centre and Northwick Park Hospital, Harrow, Middlesex, and the Bacterial Metabolism Research Laboratory, Central Public Health Laboratory, London, U.K.

S. P. BorrielloThe Clinical Research Centre and Northwick Park Hospital, Harrow, Middlesex, and the Bacterial Metabolism Research Laboratory, Central Public Health Laboratory, London, U.K.

F. E. BarclayThe Clinical Research Centre and Northwick Park Hospital, Harrow, Middlesex, and the Bacterial Metabolism Research Laboratory, Central Public Health Laboratory, London, U.K.

B. A. BartholomewThe Clinical Research Centre and Northwick Park Hospital, Harrow, Middlesex, and the Bacterial Metabolism Research Laboratory, Central Public Health Laboratory, London, U.K.

M. J. HillThe Clinical Research Centre and Northwick Park Hospital, Harrow, Middlesex, and the Bacterial Metabolism Research Laboratory, Central Public Health Laboratory, London, U.K.

Abstract

The degree and type of bacterial colonization was similar in achlorhydric patients with either severe primary hypogammaglobulinaemia or classical pernicious anaemia. This suggests that antibodies do not play a significant part in controlling the gastric flora in achlorhydric patients. The nitrite concentration in gastric juice was higher in the hypogammaglobulinaemia patients, raising the possibility that these patients may have very high levels of nitrite-derived mutagenic compounds in their gastric juice. This may account for the high incidence of gastric cancer in these patients.

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Bacterial Colonization and Nitrite Concentration in the Achlorhydric Stomachs of Patients with Primary Hypogammaglobulinaemia or Classical Pernicious Anaemia

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Bacterial Colonization and Nitrite Concentration in the Achlorhydric Stomachs of Patients with Primary Hypogammaglobulinaemia or Classical Pernicious Anaemia

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