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Original Articles

Specific Beta-Adrenergic Mechanisms in the Hypoglycaemic Activation of Gastrin and Gastric Acid Secretion

Pages 339-342 | Received 14 Apr 1983, Accepted 10 Jun 1983, Published online: 30 Apr 2018
 

Abstract

To study whether specific beta-adrenergic mechanisms contribute to the hypoglycaemic activation of gastrin and gastric acid secretion, the effects of racemic and dextroisomer propranolol (0.1 mg/kg, intravenously) were studied during insulin tests (0.2 IU/kg) in 13 persons. dl-Propranolol inhibited the gastrin response to hypoglycaemia markedly and more than the insignificant alteration observed after d-propranolol. Gastric acid response to hypoglycaemia was significantly reduced by dl-propranolol and not by d-propranolol. The findings demonstrate that non-beta-adrenergic effects of propranolol on the stomach are minor and that specific beta- adrenergic mechanisms are directly or indirectly involved in the hypoglycaemic stimulation of the stomach.

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