Screening for Occult Faecal Blood Loss in a Community by Means of Hemoccult®II Slides and a Tetramethylbenzidine Test

J. H. DybdahlLaboratory of Gastroenterology, Dept. 9, Internal Medicine, Ullevål Hospital, Oslo; Institute of General Practice, University of Bergen, Bergen; and Depts. of Surgery, Diagnostic Radiology, and Internal Medicine, Haukeland University Hospital, Bergen; Norway

K. HaugLaboratory of Gastroenterology, Dept. 9, Internal Medicine, Ullevål Hospital, Oslo; Institute of General Practice, University of Bergen, Bergen; and Depts. of Surgery, Diagnostic Radiology, and Internal Medicine, Haukeland University Hospital, Bergen; Norway

K. BakkevoldLaboratory of Gastroenterology, Dept. 9, Internal Medicine, Ullevål Hospital, Oslo; Institute of General Practice, University of Bergen, Bergen; and Depts. of Surgery, Diagnostic Radiology, and Internal Medicine, Haukeland University Hospital, Bergen; Norway

K. O. OlsenLaboratory of Gastroenterology, Dept. 9, Internal Medicine, Ullevål Hospital, Oslo; Institute of General Practice, University of Bergen, Bergen; and Depts. of Surgery, Diagnostic Radiology, and Internal Medicine, Haukeland University Hospital, Bergen; Norway

K. VetvikLaboratory of Gastroenterology, Dept. 9, Internal Medicine, Ullevål Hospital, Oslo; Institute of General Practice, University of Bergen, Bergen; and Depts. of Surgery, Diagnostic Radiology, and Internal Medicine, Haukeland University Hospital, Bergen; Norway

Abstract

A total of 754 persons statistically selected from the age group 54–64 years were asked by letter to provide faecal samples for screening of occult blood during dietary restrictions. A total of 413 persons (55%) returned an average of 5.8 (range, 1–6) faecal samples each. All the faecal specimens were analysed with Hemoccult®II slides and the 3,3', 5.5'-tetramethylbenzidine (TMB) test 0.10%. For technical reasons, however, the Hemoccult test could not be evaluated. The TMB test showed faecal blood in 50 persons. A case history was obtained in 49 persons, of whom 47 agreed to further clinical, radiological, and endoscopic investigations. The most important findings in these examinations were resectable colonic carcinoma (Dukes's stage B) in 1 subject, a gastric ulcer in 1. haemorrhagic gastritis in 1, duodenal ulcers in 2, and colorectal polyps in 11 persons. The cost of the study was estimated to be NOK 114,000 (about USD 16.000).

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Screening for Occult Faecal Blood Loss in a Community by Means of Hemoccult®II Slides and a Tetramethylbenzidine Test

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Screening for Occult Faecal Blood Loss in a Community by Means of Hemoccult®II Slides and a Tetramethylbenzidine Test

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