![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
The effect of thyrotropin-releasing hormone (TRH) on the human lower esophageal sphincter pressure (LESP) was studied in eight healthy volunteers. After injection of 200 μg TRH intravenously LESP fell from 10.6 (SD, 1.6) to 6.4 (SD, 2.3) mm Hg after 5 min, to 7.5 (SD, 3.0) mm Hg after 10 min, and to 8.0 (SD, 2.7) mm Hg after 15 min. These data were compared with change in LESP after injection of 0.9% NaCl (no. = 8), and we found significant difference (p < 0.05) in LESP after 5, 10, and 15 min. Whether this response was a direct myogenic effect on the LES or an indirect action via the dopaminergic nerve system requires further investigation.