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Scandinavian Journal of Gastroenterology Volume 19, 1984 - Issue 5
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Original Articles

Effect of Doxepin on Gastric Secretion in Man

K.-E. GierckskyInstitute of Clinical Medicine, University of Tromsø, Tromsø, Norway
,
D. ØyenInstitute of Clinical Medicine, University of Tromsø, Tromsø, Norway
,
O. K. AndersenInstitute of Clinical Medicine, University of Tromsø, Tromsø, Norway
&
P. BurholInstitute of Clinical Medicine, University of Tromsø, Tromsø, Norway
Pages 661-664 | Received 27 Jun 1983, Accepted 08 Nov 1983, Published online: 30 Apr 2018
 
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Abstract

The effect of doxepin, a tricyclic antidepressive agent, on gastric secretion of acid and pepsin was studied in five healthy students. Dose-response studies were carried out on different days with increasing doses of doxepin on a constant background stimulation with pentagastrin and with increasing doses of pentagastrin in combination with a constant dose of doxepin. Doxepin reduced gastric acid secretion when serum values of doxepin were above 60 nmol/l.

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