A Double-Blind Randomized Trial of Cimetidine in Acute Upper Gastrointestinal Bleeding

G. G. BirnieDepts. of Gastroenterology and Surgery, Western Infirmary and Gartnavel General Hospital, and the UniversityDepartment of Statistics, Glasgow University, Glasgow, U.K.

E. M. M. QuigleyDepts. of Gastroenterology and Surgery, Western Infirmary and Gartnavel General Hospital, and the UniversityDepartment of Statistics, Glasgow University, Glasgow, U.K.

G. AllanDepts. of Gastroenterology and Surgery, Western Infirmary and Gartnavel General Hospital, and the UniversityDepartment of Statistics, Glasgow University, Glasgow, U.K.

B. M. GoudieDepts. of Gastroenterology and Surgery, Western Infirmary and Gartnavel General Hospital, and the UniversityDepartment of Statistics, Glasgow University, Glasgow, U.K.

F. KennedyDepts. of Gastroenterology and Surgery, Western Infirmary and Gartnavel General Hospital, and the UniversityDepartment of Statistics, Glasgow University, Glasgow, U.K.

K. E. L. McCollDepts. of Gastroenterology and Surgery, Western Infirmary and Gartnavel General Hospital, and the UniversityDepartment of Statistics, Glasgow University, Glasgow, U.K.

C. MacKayDepts. of Gastroenterology and Surgery, Western Infirmary and Gartnavel General Hospital, and the UniversityDepartment of Statistics, Glasgow University, Glasgow, U.K.

G. D. MurrayDepts. of Gastroenterology and Surgery, Western Infirmary and Gartnavel General Hospital, and the UniversityDepartment of Statistics, Glasgow University, Glasgow, U.K.

W. MurrayDepts. of Gastroenterology and Surgery, Western Infirmary and Gartnavel General Hospital, and the UniversityDepartment of Statistics, Glasgow University, Glasgow, U.K.

R. PickardDepts. of Gastroenterology and Surgery, Western Infirmary and Gartnavel General Hospital, and the UniversityDepartment of Statistics, Glasgow University, Glasgow, U.K.

B. SugdenDepts. of Gastroenterology and Surgery, Western Infirmary and Gartnavel General Hospital, and the UniversityDepartment of Statistics, Glasgow University, Glasgow, U.K.

G. WatkinsonDepts. of Gastroenterology and Surgery, Western Infirmary and Gartnavel General Hospital, and the UniversityDepartment of Statistics, Glasgow University, Glasgow, U.K.

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Abstract

Two hundred and thirteen patients were studied in a double-blind trial of cimetidine versus placebo in the treatment of acute upper gastrointestinal haemorrhage. One hundred and six patients were randomly allocated to receive cimetidine and 107 to receive placebo. There was no significant reduction in transfusion requirements, incidence of further haemorrhage, length of stay in hospital, or mortality in the treated group. There was no subgroup of patients with acute upper gastrointestinal bleeding which appeared to benefit from treatment with cimetidine.

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A Double-Blind Randomized Trial of Cimetidine in Acute Upper Gastrointestinal Bleeding

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A Double-Blind Randomized Trial of Cimetidine in Acute Upper Gastrointestinal Bleeding

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