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Original Articles

A Double-Blind Endoscopic Study with De-Nol® Tablets and Cimetidine for Duodenal Ulcer

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Pages 905-908 | Received 03 Nov 1983, Accepted 10 Dec 1983, Published online: 30 Apr 2018
 

Abstract

In a double-blind, double-dummy comparison of short-term ulcer healing, involving 50 patients treated with either De-Nol® tablets (four times daily) or Cimetidine tablets (400 mg. twice daily), no statistical difference in healing rates was observed after 8 weeks' treatment. There was, however, a numerical trend in favour of De-Nol (De-Nol. 100% healed; Cimetidine, 88% healed). Statistical significance in favour of De-Nol was observed, however, in the reduction of antacid tablet consumption and relief of ulcer pain. No unwanted side effects were observed with either drug. This trial indicates that De-Nol and cimetidine are equally effective and useful in the short-term treatment of duodenal ulcer.

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