Doxepin in the Treatment of Duodenal Ulcer

A Double-Blind Clinical Study Comparing Doxepin and Placebo

O. K. AndersenDept. of Surgery, University of Tromsø, Tromsø, and Dept. of Internal Medicine, Rogaland County Hospital, Stavanger, Norway

J. Bergsåker-AspøyDept. of Surgery, University of Tromsø, Tromsø, and Dept. of Internal Medicine, Rogaland County Hospital, Stavanger, Norway

L. HalvorsenDept. of Surgery, University of Tromsø, Tromsø, and Dept. of Internal Medicine, Rogaland County Hospital, Stavanger, Norway

K.-E. GierckskyDept. of Surgery, University of Tromsø, Tromsø, and Dept. of Internal Medicine, Rogaland County Hospital, Stavanger, Norway

Abstract

In the double-blind study of 51 patients with duodenal ulcer the effect of doxepin and placebo was evaluated. Complete healing of the ulcer was found in 19 of 23 patients after 4 weeks of treatment with 50 mg doxepin (83%) and in 14 of 27 patients given placebo (52%) (p < 0.05). Two patients in the placebo group developed complications necessitating surgical intervention. No serious side effects were registered in the doxepin group.

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Doxepin in the Treatment of Duodenal Ulcer

A Double-Blind Clinical Study Comparing Doxepin and Placebo

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Doxepin in the Treatment of Duodenal Ulcer

A Double-Blind Clinical Study Comparing Doxepin and Placebo

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