Prevalence and risk factors for venous thromboembolic complications in the Swiss Inflammatory Bowel Disease Cohort

Abstract

Objective: Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is associated with the occurrence of venous thromboembolism (VTE) such as deep vein thrombosis (DVT) and pulmonary embolism (PE). We aimed to assess the prevalence and associated risk factors for VTE in a large national cohort of IBD patients.

Material and methods: Data from patients of the Swiss IBD Cohort Study (SIBDCS) enrolled between 2006 and 2013 were analyzed.

Results: A total of 2284 IBD patients were analyzed of which 1324 suffered from CD and 960 from UC. VTE prevalence was 3.9% (90/2284) overall and 3.4% (45/1324) in CD patients (whereof 2.4% suffered from DVT and 1.5% from PE) and 4.7% (45/960) in UC patients (whereof 3.2% suffered from DVT and 2.4% from PE). Median disease duration in CD patients with VTE was 12 years [IQR 8–23] compared to eight years [3–16] in CD patients without VTE (p = 0.001). Disease duration in UC patients with VTE was seven years [4–18] compared to six years [2–13] in UC patients without VTE (p = 0.051). Age at CD diagnosis ≥40 years (OR 1.851, p = 0.073) and disease duration >10 years (OR 1.771, p = 0.088) showed a trend to be associated with VTE. In UC patients, IBD-related surgery (OR 3.396, p = 0.004) and pancolitis (OR 1.927, p = 0.050) were significantly associated with VTE.

Conclusions: VTE are prevalent in CD and UC patients. Pancolitis and UC-related surgery are significantly associated with VTE in UC patients.

Keywords:

• Crohn's disease
• thromboembolic complications
• ulcerative colitis
• venous thromboembolism

Acknowledgements

The authors thank all members of the SIBDCS who were involved in the acquisition of data:

Claudia Anderegg; Peter Bauerfeind; Christoph Beglinger; Stefan Begré; Dominique Belli; José Bengoa; Luc Biedermann; Janek Binek; Mirjam Blattmann; Nadia Blickenstorfer; Stephan Boehm; Jan Borovicka; Christian Braegger; Patrick Bühr; Bernard Burnand; Emmanuel Burri; Sophie Buyse; Matthias Cremer; Dominique Criblez; Philippe de Saussure; Lukas Degen; Joakim Delarive; Christopher Dörig; Barbara Dora; Gian Dorta; Tobias Ehmann; Ali El Wafa; Mara Egger; Matthias Engelmann; Christian Felley; Markus Fliegner; Nicolas Fournier; Montserrat Fraga; Alain Frei; Pascal Frei; Remus Frei; Michael Fried; Florian Froehlich; Raoul Furlano; Suzanne Gallot-Lavallée; Martin Geyer; Marc Girardin; Delphine Golay; Tanja Grandinetti; Beat Gysi; Horst Haack; Johannes Haarer; Beat Helbling; Peter Hengstler; Denise Herzog; Cyrill Hess; Klaas Heyland; Thomas Hinterleitner; Philippe Hiroz; Claudia Hirschi; Petr Hruz; Pascal Juillerat; Rosmarie Junker; Christina Knellwolf; Christoph Knoblauch; Henrik Köhler; Rebekka Koller; Claudia Krieger; Gerd A. Kullak-Ublick; Markus Landolt; Frank Lehmann; Valérie McLin; Philippe Maerten; Michel Maillard; Christine Manser; Urs Marbet; Michael Manz; George Marx; Rémy Meier; Christa Meyenberger; Jonathan Meyer; Pierre Michetti; Benjamin Misselwitz; Darius Moradpour; Patrick Mosler; Christian Mottet; Christoph Müller; Pascal Müller; Beat Müllhaupt; Claudia Münger; Leilla Musso; Andreas Nagy; Cristina Nichita; Natacha Noël; Andreas Nydegger; Maliza Nzabonimpa; Nicole Obialo; Carl Oneta; Cassandra Oropesa; Laetitia-Marie Petit; Franziska Piccoli; Julia Pilz; Gaëlle Pittet; Valérie Pittet; Bruno Raffa; Ronald Rentsch; Sophie Restellini, Jean-Pierre Richterich; Silvia Rihs; Jocelyn Roduit; Daniela Rogler; Gerhard Rogler; Jean-Benoît Rossel; Markus Sagmeister; Gaby Saner; Bernhard Sauter; Mikael Sawatzki; Michael Scharl; Sylvie Scharl; Nora Schaub; Martin Schelling; Susanne Schibli; Hugo Schlauri; Daniela Schmid; Sybille Schmid; Jean-François Schnegg; Alain Schoepfer; Christiane Sokollik; Frank Seibold; Gian-Marco Semadeni; Mariam Seirafi; David Semela; Arne Senning; Marc Sidler; Johannes Spalinger; Holger Spangenberger; Philippe Stadler; Volker Stenz; Michael Steuerwald; Alex Straumann; Michael Sulz; Alexandra Suter; Michela Tempia-Caliera; Joël Thorens; Sarah Tiedemann; Stephan Vavricka; Francesco Viani; Roland Von Känel; Alain Vonlaufen; Dominique Vouillamoz; Rachel Vulliamy; Helene Werner; Paul Wiesel; Reiner Wiest; Tina Wylie; Jonas Zeitz; Dorothee Zimmermann.

Disclosure statement

The authors have no disclosures relevant to the manuscript.

Writing assistance: none.

Guarantor of the article: Alain M. Schoepfer.

This manuscript, including related data, figures and tables have not been previously published and the manuscript is not under consideration elsewhere.

Funding information

This work was supported by grants from the Swiss National Science Foundation (33CS30_148422 to Swiss IBD Cohort Study group, 32003B_135664/1 to AMS, 320000-114009/3 and 32473B_135694/1 to SRV), and unrestricted research grants from Otsuka Switzerland, Takeda Switzerland, and Tillotts Switzerland. This is an investigator-initiated study; pharmaceutical companies played no role in study design, acquisition, analysis, interpretation or presentation of the data.