Abstract
Background/objective: Hiatal hernia is considered to be a predisposing factor to develop Mallory-Weiss Syndrome (MWS). No large case–control studies verifying this hypothesis have been conducted.
Methods: We reviewed all esophagogastroduodenoscopies with findings of MWS (n = 2342) in a national database and compared with age and gender-matched controls (n = 9368). Demographics, endoscopic characteristics and presence of a hiatal hernia were compared between both groups. Average age was 56.7 ± 18.6 years, and 72.4% were male.
Results: Hiatal hernia was more common in controls, and no significant difference was seen in a multivariate analysis.
Conclusion: Dynamic changes inducing mucosal tension are more relevant determinants to develop MWS than gastro-esophageal junction location alone.
Acknowledgements
The data from the CORI reported here were supplied by the NIDDK Central Repositories. This manuscript was not prepared in collaboration with the CORI group and does not necessarily reflect the opinions or views of the CORI group, the NIDDK Central Repositories, or the NIDDK.
Disclosure statement
The authors declare no conflict of interest.