Abstract
Background/Aims: Anxiety and depression are common comorbid psychiatric disorders in IBS patients, but the population-level determinants influencing these comorbidities in IBS patients are poorly understood. We sought to determine whether there was an association between comorbid affective disorders and socioeconomic status among irritable bowel syndrome (IBS) patients.
Methods: We assembled a retrospective cohort of 1074 IBS patients with comorbid Generalized Anxiety Disorder (GAD) and/or Major Depressive Disorder (MDD) seen at two tertiary referral centers between 2007 and 2015. IBS patients with comorbid GAD and/or MDD were matched 3:1 by age, sex, and race to controls with IBS and no history of comorbid GAD and/or MDD. Socioeconomic status was approximated by patient zip codes.
Results: IBS patients in the lowest socioeconomic group were more likely to be diagnosed with GAD and/or MDD compared to controls (OR = 1.38, p = .0004). The median average per capita income for comorbid GAD/MDD IBS patient cohort was also significantly lower than the control IBS patient cohort ($39,880.50 vs. $41,277.00, p = .02).
Conclusions: Among IBS patients, the presence of comorbid Generalized Anxiety Disorder and/or Major Depressive Disorder is associated with lower socioeconomic status and lower average per capita income. These findings speak to a biopsychosocial model of illness, which should be considered by clinicians in the care of IBS patients.
Author contributions
K. Staller and C. Silvernale planned and designed the study. K. Staller and C. Silvernale collected and analyzed the data; C. Silvernale drafted the manuscript; all authors interpreted the results and contributed to critical review of the manuscript.
K. Staller had full access to all the data in the study and takes responsibility for the integrity of the data and accuracy of the data analysis.
All authors approved the final version of the article, including the authorship list.
Disclosure statement
C. Silvernale reports no disclosures. B. Kuo has served as a consultant at Actavis Pharma Inc, AstraZeneca, Biogen, Entrega, Forest Pharmaceuticals, Gelesis, Ironwood Pharmaceuticals, Takeda, Theravance, Genzyme, Covidien/Given Imaging, and Vibrant Ltd. K. Staller has served as a consultant at Bayer, Shire, and Synergy; served as a speaker for Shire. No potential conflict of interest was reported by the authors.