Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae

Abstract

Clostridioides difficile infection may be complicated by co-infection with other pathogens. We here describe the successful use of faecal microbiota transplantation to eradicate concomitant C. difficile and extensively drug-resistant (XDR) KPC-producing Klebsiella pneumoniae. Donor microbiota efficiently engrafted in the patient, and a donor-like microbial assemblage persisted in the patient during six months follow-up. The report explores the potential for the donor microbiota to eradicate and replace multi-resistant microorganisms.

Keywords:

• Faecal microbiota transplantation
• Clostridioides difficile
• Klebsiella pneumoniae
• drug resistance

Acknowledgements

The authors thank Bodil Madsen for excellent technical support as well as Marlene Danner Dalgaard and NeslihanBicen at the DTU Multi-Assay Core facility for performing the 16S rRNA sequencing.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The present work was in part funded by the Danish Regions Medical Fund (j.no. 14/217) and Innovation Fund Denmark [grant no. 8056-00006B].