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Original Article

Complications and adverse effects related to surgical and medical treatment in patients with inflammatory bowel disease in a prospectively recruited population-based cohort

ORCID Icon, ORCID Icon & ORCID Icon
Pages 1296-1303 | Received 22 Jun 2021, Accepted 23 Jul 2021, Published online: 08 Aug 2021
 

Abstract

Background

Medical adverse effects and surgical complications have been reported during treatment of patients with inflammatory bowel diseases (IBDs). There is however a shortage of studies describing these in the same cohort of patients.

Aim

To describe medical adverse effects and surgical complications in a prospectively followed population-based cohort of patients followed for at least 10 years.

Methods

All newly diagnosed patients with ulcerative colitis (UC) and Crohn’s disease (CD) in the county of Uppsala between 2005 and 2009 were prospectively followed. At the end of 2019, the medical notes were scrutinised and all medical adverse effects and postoperative surgical complications were registered.

Results

A total of 330 patients with UC and 153 patients with CD in all age groups were included in the cohort. Four hundred and forty-two of these (91.5%) could be followed for 10 years or until death. One hundred and twenty-two patients (26.9%) experienced one or more adverse effects during the pharmacological treatment, and 25 of these could be classified as serious. Fifty-seven malignancies were diagnosed during the observation time. Surgery was performed in 16/330 UC and 33/153 CD patients. Frequency of early postoperative complications was 31% for UC patients and 36% for CD patients. Most complications were minor but two patients were re-operated, two needed intensive care and one patient died postoperatively.

Conclusions

Adverse effects related to medical therapy were experienced by approximately every fourth patient, and by every third patient that was operated.

Acknowledgements

This manuscript was presented as a poster at the UEGW 2020.

Author contributions

AR and UK designed the study, AR collected the medical data and UK the surgical data. AR performed the statistical analysis. ÖL analysed the data concerning steroid effects on the skeleton. All authors wrote the manuscript and reviewed and approved the final version of the manuscript.

Guarantor of the article: Anders Rönnblom.

Disclosure statement

The authors have no conflicts of interest to declare.

Additional information

Funding

This work was supported by grants from the Uppsala University Hospital Research Foundation.

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