Abstract
Background and study aims
Sporadic fundic gland polyps (FGP) are the most common type of gastric polyp, reported in 0.8%–1.9% of patients undergoing Esophagogastroduodenoscopy (EGD). Data on long-term outcomes of large FGP is limited. We aim to study the natural history of sporadic large (≥ 10 mm) FGPs.
Patients and methods
All adults who underwent EGD for any indication from April 2014 to December 2019 at a tertiary care center were retrospectively assessed, and patients with FGP (≥10mm) were identified. Data on baseline characteristics and long-term outcomes were recorded. Follow-up data were recorded for patients who underwent repeat endoscopy to evaluate for rates of dysplasia and cancer.
Results
A total of 4,000 patients with a diagnosis of FGP were screened and 132 large, biopsy-proven FGPs were included in the final analysis. The most common indication for EGD was gastroesophageal reflux disease (61%). During a follow-up period of 3.2 years, the rate of dysplasia, was 4.0%. Subgroup analysis based on size (10–19 mm and ≥ 20 mm) showed no significant difference in overall outcomes.
Conclusion
Repeat EGDs for surveillance should not be routinely performed since large (≥10 mm) sporadic FGPs are mostly benign without significant malignant potential.
Disclosure statement
The author(s) have nothing to disclose. All author(s) disclose that there are NO potential conflicts (financial, professional, or personal) that are relevant to the manuscript.