A glimpse of research cores and frontiers on the relationship between long noncoding RNAs (lncRNAs) and colorectal cancer (CRC) using the VOSviewer tool

Abstract

As lncRNAs are essential participants in colorectal carcinogenesis. This study aimed to use the VOSviewer tool to access the research cores and frontiers on the relationship between lncRNAs and CRC. Our findings showed that the mechanism of lncRNA in the occurrence and development of CRC was the core theme of the field. (1) Immunotherapy and immune microenvironment of CRC and lncRNAs, (2) CRC and lncRNAs in exosomes and (3) CRC and lncRNA-targeted therapy might represent three research frontiers. A comprehensive understanding of their existing mechanisms and the search for new regulatory paradigms are the core topics of future research. This knowledge will also help us select appropriate targeting methods and select appropriate preclinical models to promote clinical translation and ultimately achieve precise treatment of CRC.

Keywords:

• CRC
• lncRNA
• bibliometric analysis
• research trend
• precision treatment

Acknowledgments

This study was supported by the Doctoral Research Initiation Fund of Affiliated Hospital of Southwest Medical University (No. 21041). Besides, thanks to BioRender.com (https://app.biorender.com/biorender-templates) for supporting the drawings in this article.

Disclosure statement

The author reports no conflicts of interest in this work.

Additional information

Funding

This study was supported by the Doctoral Research Initiation Fund of Affiliated Hospital of Southwest Medical University [No. 21041].