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Scandinavian Journal of Gastroenterology Volume 33, 1998 - Issue 4
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Research Article

Role of Interleukin-10 in a Murine Model of Dextran Sulfate Sodium-Induced Colitis

M. TOMOYOSE, K. MITSUYAMA, H. ISHIDA, A. TOYONAGA, K. TANIKAWA
Pages 435-440 | Published online: 08 Jul 2009
 
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Abstract

Background: Increased production of proinflammatory cytokines is characteristic of both animal models of experimental colitis and human inflammatory bowel disease. This study was designed to characterize the functional role of interleukin (IL)-10 in a murine model of experimental colitis. Methods: Cytokine profiles were analyzed in animals with dextran sulfate sodium-induced colitis. The effect of treatment with IL-10 or anti-IL-10 antibodies on colonic cytokine production in vitro and tissue damage in vivo were evaluated. Results

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