Effects of Cisapride on Symptoms and Postcibal Small-Bowel Motor Function in Patients with Irritable Bowel Syndrome

Abstract

Background: Irritable bowel syndrome is a common cause of abdominal pain and discomfort and may be related to disordered gastrointestinal motility. Our aim was to assess the effects of long-term treatment with a prokinetic agent, cisapride, on postprandial jejunal motility and symptoms in the irritable bowel syndrome (IBS). Methods: Thirty-eight patients with IBS (constipation-predominant, n = 17; diarrhoea-predominant, n = 21) underwent 24-h ambulatory jejunal manometry before and after 12 week's treatment {cisapride, 5mg three times daily (n = 19) or placebo (n = 19)}. Results