BB-10010, an Analogue of Macrophage Inflammatory Protein-1 Alpha, Reduces Proliferation in Murine Small-Intestinal Crypts

Abstract

Background: The small-intestinal epithelium, a rapidly proliferating tissue, is highly sensitive to cycle-specific agents such as radiation. Macrophage inflammatory protein (MIP)-1 alpha has been shown to reduce cell proliferation in bone marrow, seminiferous epithelium, and skin. The current work investigates the activity of an MIP-1 alpha variant, BB-10010, in the gut. Methods